Dosage forms for oral administration of zoledronic acid or related compounds for treating disease

A method of delivering zoledronic acid to the blood of a human being comprising orally administering zoledronic acid in the disodium salt form to a human being in need of treatment with zoledronic acid, wherein the human being is instructed not to eat or drink for at least 1 hour before and at least 30 minutes after the zoledronic acid in the disodium salt form is administered, wherein the zoledronic acid in the disodium salt form is administered in an amount and frequency that results in an AUC of zoledronic acid that is about 100 ng·h/mL to about 2000 ng·h/mL each time the zoledronic acid in the disodium salt form is administered.

A method of delivering zoledronic acid to the blood of a human being comprising orally administering zoledronic acid in the disodium salt form to a human being in need of treatment with zoledronic acid;

• wherein the zoledronic acid in the disodium salt form is administered at least once weekly and no more often than once daily and in a manner that results in a bioavailability of zoledronic acid in the human being of 1% to about 4% after each administration.