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US 9,517,238 B2Granted
Compositions and methods for treating allergic inflammation through inhibition of NTRK1
AssigneeChildren's Hospital Medical Center
InventorsMark Rochman, Marc E. Rothenberg
Life of this patent
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Abstract
The invention provides methods of treating allergic inflammatory conditions using an anti-neurotrophin tyrosine kinase receptor 1 (NTRK1)-based therapeutic agent, and related compositions and methods.
Claims10
A method of treating eosinophilic esophagitis (EoE) in a human subject in need thereof, comprising administering to the subject an amount of a tyrosine kinase inhibitor effective to suppress NTRK1 activity in target cells of the human subject, wherein the tyrosine kinase inhibitor is lestaurtinib (CEP-701) or crizotinib.
Dependencies are inferred from the claim text.