Local cochlear application of statins for stimulating neurite regrowth in the cochlea
AssigneeNorthwestern University
InventorsDonna S. Whitlon, Claus-Peter Richter
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Abstract
Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear, as well as methods and kits for preventing damage to or treating damage of auditory neurons and/or hair cells of the cochlea following acoustic or toxic insult. An exemplary statin for these methods and kits includes Pitavastatin having the compound formula (VIII):
Claims16
A method of stimulating neurite growth from spiral ganglion neurons in an inner ear, comprising:
- contacting a neurite with a statin, or a pharmaceutically acceptable salt thereof, wherein the statin comprises a compound selected from a group consisting of compounds having formulas (II)-(VIII):
- or a combination thereof.
A method of preventing or treating hearing loss in a subject, comprising:
- administering to the subject a statin or a pharmaceutically acceptable salt thereof, wherein the statin comprises a compound selected from a group consisting of compounds having formulas (II)-(VIII):
- or a combination thereof.
A kit for preventing or treating hearing loss in a subject, comprising:
- a statin comprising a compound selected from a group consisting of compounds having formulas (II)-(VIII):
- or a combination thereof;
- and
- instructions for administering to the subject the statin or a pharmaceutically acceptable salt thereof to prevent or treat hearing loss in the subject.
Dependencies are inferred from the claim text.