A pharmaceutical composition for pro re nata (p.r.n.) treatment of anxiety disorders and/or the symptoms thereof, consisting essentially of a combination of at least one beta adrenergic receptor antagonist agent and/or pharmaceutically acceptable salts thereof, and at least one antiemetic muscarinic receptor antagonist agent and/or pharmaceutically acceptable salts thereof, together with one or more pharmaceutically acceptable excipients, wherein the at least one beta adrenergic receptor antagonist agent and the at least one antiemetic muscarinic receptor antagonist agent are combined in amounts therapeutically effective for p.r.n. symptomatic treatment of a subject and wherein the pharmaceutical composition is in a form for mucosal, sublingual, buccal, rectal, vaginal, nasal, or oral p.r.n. administration by a subject anticipating symptoms of an anxiety disorder and/or experiencing symptoms of an anxiety disorder.