Small molecule RNase inhibitors and methods of use
AssigneesUniversity of Rochester, Board of Regents of the University of Nebraska, Temple University of the Commonwealth System of Higher Education
InventorsPaul M. Dunman, Patrick D. Olson, Wayne Childers
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Abstract
Small molecule inhibitors of bacterial ribonuclease (e.g., RnpA) and methods for their synthesis and use are described herein. The methods of using the compounds include treating and preventing microbial infections and inhibiting bacterial ribonuclease.
Claims10
A method of treating, reducing, or inhibiting a bacterial infection in a subject, comprising administering to the subject an effective amount of an RNase inhibitor of the following structure:
- or a pharmaceutically acceptable salt or prodrug thereof,
- wherein the bacterial infection is a Staphylococcus infection.
A method of inhibiting a bacterial ribonuclease comprising contacting the bacterial ribonuclease with an effective amount of an RNase inhibitor of the following structure:
- or a pharmaceutically acceptable salt or prodrug thereof,
- wherein the bacterial ribonuclease is Staphylococcus aureus RNase P.
Dependencies are inferred from the claim text.