Dermal matrix and production method thereof having synergistic effects comprising microparticles which provides tissue repair

A method for producing a dermal matrix system with micro particles, comprising:

• preparing the dermal matrix system;
• preparing the micro particles;
• and
• combining the micro particles with the dermal matrix system,
• wherein the step of preparing the dermal matrix system further comprises,
• preparing a collagen solution,
• adding laminin into the collagen solution and forming a first mixture,
• freezing and storing the first mixture,
• lyophilizing the first mixture and forming a lyophilizate,
• cross linking the lyophilizate,
• wherein the step of preparing the micro particles further comprises,
• preparing an aqueous polymer solution, wherein the aqueous polymer solution is prepared by dissolving a hyaluronic acid (HA) in pure water,
• preparing a second mixture of phospholipid, an antioxidant agent and alcohol, wherein the second mixture is formed by adding dipalmitoylphosphatidylcholine (DPPC) and resveratrol into the alcohol,
• adding the aqueous polymer solution into the second mixture to form a third mixture,
• drying the third mixture to obtain the micro particles,
• wherein in the step of combining the micro particles with the dermal matrix system, the micro particles are sprayed onto the dermal matrix system.