Pharmaceutical composition for inhalation
AssigneesShionogi & Co., Ltd., Shizuoka Prefectural Universities Corporation
InventorsSatomi Onoue, Shizuo Yamada
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Abstract
The present invention relates to a powder formulation which reduces side effect risk of a medicine having a side effect of drug-induced photodermatosis and increases therapeutic effect, and relates to the method for producing the same. Said powder formulation makes inhalation therapy possible by carrying out aerosolization easily, and since pharmacological effect in lung local part is increased, it is possible to decrease the dose. Skin transmigration of said medicine is controlled by a lung specific delivery technology, and photodermatosis which is a side effect can be controlled.
Claims15
A powder formulation comprising:
- (i) micronized particles with a mean particle diameter of 20 μm or less comprising
- (i-1) pirfenidone and
- (i-2) at least one excipient selected from the group consisting of a saccharide, a sugar alcohol, a fatty acid and salts thereof, a wax, calcium sulfate, calcium carbonate, talc and titanium oxide,
- wherein the micronized particles exclude a polymer, and
- (ii) a carrier with a mean particle diameter of 10 to 200 μm, wherein the micronized particles are adhered to the carrier.
Dependencies are inferred from the claim text.