Polymer particle delivery compositions and methods of use

A polymer particle delivery composition comprising a therapeutically effective amount of at least one bioactive agent dispersed in a biodegradable polymer, wherein the polymer is

• a polyester amide having a chemical formula described by structural Formula III:
• wherein
• n ranges from about 5 to about 150;
• m ranges about 0.1 to 0.9;
• p ranges from about 0.9 to 0.1;
• R1 is independently selected from residues of α,ω-bis(4-carboxyphenoxy)-(C1-C8) alkane, 3,3′-(alkanedioyldioxy)dicinnamic acid or 4,4′-(alkanedioyldioxy)dicinnamic acid, (C2-C20) alkylene, (C2-C20) alkenylene
• each R2 is independently hydrogen, (C1-C12) alkyl or (C6-C10) aryl or a protecting group;
• the R3s within an individual m monomer are independently selected from the group consisting of hydrogen, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C6-C10) aryl (C1-C6) alkyl;
• and
• R4 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, (C2-C8) alkyloxy, bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural Formula(II)
• and combinations thereof.