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AssigneeRutgers, The State University of New Jersey
InventorsPatrick J. Sinko, Stanley Stein, Hilliard Kutscher, Manjeet Deshmukh, Anupa Menjoge, Yashveer Singh, Simi Gunaseelan
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Novel classes of multi-arm polyalkylene oxide-based materials including PEG nanocarriers, nanogel particles, and aggregated nanogel particles are disclosed. These classes of compositions may be associated with therapeutic agents and targeting moieties, or visibility enhancing agents, and may have a modified surface structure. In some embodiments the PEG-based materials can be made to provide relatively high drug loads with improved solubility and targeted delivery.
A nanocarrier, comprising two doxorubicin molecules (Dox) coupled to at least one end of a linear polyalkylene oxide or a four-arm polyalkylene oxide by the linker Glu(Leu-Gly)2 SEQ ID No:
Dependencies are inferred from the claim text.