Treatment for chronic myocardial infarct
AssigneeBioCardia, Inc.
InventorsLuis M. de la Fuente, Simon H. Stertzer, Julio Argentieri, Eduardo Penaloza, Peter A. Altman
Life of this patent
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Abstract
A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (ABM) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (MI) patients. The treatment is safe and improves ejection fraction (EF).
Claims40
A method of treating chronic myocardial infarction comprising:
- identifying a patient with chronic myocardial infarction with areas of chronic myocardial infarct within the patient's myocardium;
- and
- transendocardially injecting a therapeutic preparation comprising 30,000,000 to 264,000,000 concentrated mononuclear cells into myocardium of the patient near or in an area of chronic infarcted tissue resulting from chronic myocardial infarct, where said mononuclear cells were harvested from autologous bone marrow cells from the patient.
A method of treating chronic myocardial infarction comprising:
- identifying a patient with chronic myocardial infarction with areas of chronic myocardial infarct within the patient's myocardium;
- transendocardially injecting a therapeutic preparation into the myocardium of the patient near or in areas of chronic myocardial infarct, where said therapeutic preparation comprises concentrated CD-34 positive cells and CD-133 positive cells harvested from autologous bone marrow cells of the patient and suspended in solution.
A method of treating chronic myocardial infarction comprising:
- identifying a patient with chronic myocardial infarction having an ejection fraction less than 40%;
- and
- transendocardially injecting a therapeutic preparation comprising concentrated CD-34 positive and CD-133 positive mononuclear cells into myocardium of the patient, where said mononuclear cells were harvested from autologous bone marrow cells from the patient.
A method of treating chronic myocardial infarction comprising:
- identifying a patient with areas of chronic myocardial infarct and/or ischemic tissue within the patient's myocardium 10-13 are directed at treat;
- and
- transendocardially injecting a therapeutic preparation comprising concentrated CD-34 positive and CD-133 positive mononuclear cells into myocardium of the patient near or in said areas of chronic infarcted tissue and/or ischemic tissue, where said mononuclear cells were harvested from autologous bone marrow cells from the patient and were injected with a helical needle.
A method of treating chronic myocardial infarction comprising:
- identifying a patient with areas of chronic myocardial infarct and/or ischemic tissue within the patient's myocardium;
- and
- transendocardially injecting a therapeutic preparation comprising concentrated CD-34 positive and CD-133 positive mononuclear cells into myocardium of the patient proximate said areas of chronic infarcted tissue and/or ischemic tissue, where said mononuclear cells were harvested from autologous bone marrow cells from a posterior iliac crest of the patient.
A method of treating chronic myocardial infarction comprising:
- identifying a patient with areas of chronic myocardial infarct and/or ischemic tissue within the patient's myocardium;
- and
- transendocardially injecting a therapeutic preparation comprising concentrated CD-34 positive and CD-133 positive mononuclear cells into myocardium of the patient near or in said areas of chronic infarcted tissue and/or ischemic tissue, where said mononuclear cells were harvested from autologous bone marrow cells, filtered and resuspended.
A method of treating chronic myocardial infarction comprising:
- identifying a patient with areas of chronic myocardial infarct and/or ischemic tissue within the patient's myocardium;
- and
- transendocardially injecting a therapeutic preparation comprising concentrated CD-34 positive and CD-133 positive mononuclear cells into myocardium of the patient near or in said areas of chronic infarcted tissue and/or ischemic tissue, where said mononuclear cells were harvested from adipose tissue from the patient.
A method of treating chronic myocardial infarction comprising:
- identifying a patient with areas of chronic myocardial infarct and/or ischemic tissue within the patient's myocardium;
- and
- transendocardially injecting a therapeutic preparation comprising concentrated CD-34 positive and CD-133 positive mononuclear cells into myocardium of the patient near or in said areas of chronic infarcted tissue and/or ischemic tissue, where said mononuclear cells were harvested from peripheral blood from the patient.
Dependencies are inferred from the claim text.