Apparatus for treating an organ and related methods of use

A method of treating a wall of a bladder, the wall having plurality of layers including, from inside out, a first layer, a second layer, and a third layer containing a muscle, the method comprising:

• positioning a distal end of a medical device adjacent to the wall of the bladder, the medical device comprising:
• an elongate tube having a proximal end, a distal end, and a lumen extending therebetween;
• and
• an injector disposed within the lumen of the elongate tube, the injector including a needle configured to pierce the wall;
• advancing the injector to a plurality of locations within the wall;
• and
• delivering a substance between an innermost surface of the first layer and an outermost surface of the second layer at each of the plurality of locations,
• wherein the first layer is a mucosal layer of the bladder and the second layer is a submucosal layer of the bladder,
• wherein, when delivered, the substance is configured to semi-permanently maintain a spatial separation between the first and second layers that modifies contraction of the muscle by inhibiting signal transduction for at least one month,
• wherein at least two of the plurality locations are discrete from one another.

A method of treating a wall of a bladder, the wall having a plurality of layers of tissue including, from inside out, a first layer, a second layer, and a third layer containing a detrusor muscle, the method comprising:

• positioning a distal end of a medical device adjacent to an anatomical area of the wall, the medical device comprising:
• an elongate tube having a proximal end and a distal end and a lumen extending therebetween;
• and
• an injector disposed within the lumen of the elongate tube, the injector including a needle configured to pierce the wall;
• and
• advancing the injector to a plurality of locations within the wall at the anatomical area and delivering a substance to each of the plurality of locations,
• wherein each of the plurality of locations is between an innermost surface of the first layer and an outermost surface of the second layer,
• wherein the first layer is a urothelium and, the second layer is a lamina propria, and the anatomical area includes one of a dome, an internal sphincter, or a trigone,
• wherein, when delivered, the substance is configured to maintain a spatial separation between the first and second layers that modifies contraction of the detrusor muscle by inhibiting signal transduction for at least one month, and
• wherein at least two of the plurality locations are discontinuous with one another.