US 9,517,005 B2 · Attenuation-based optic neuropathy detection with three-dimensional optical coherence tomography

Abstract

Optical coherence tomography (OCT) scan data of a subject is acquired over a region of interest which can include an optic disc or a macula of a retina. Layer boundaries of retinal layers are identified in the OCT scan data to facilitate measurements. In one aspect, a measurement related to ratio value between a total backscattered signal intensity of one or more target layers of the retina and a total backscattered signal intensity of one or more reference layers is computed on a location-by-location basis within a region of interest of the OCT scan data. Measurements can be collected, aggregated, analyzed, and displayed in connection with other information taken or derived from the OCT scan data.

Claims31

Dependent claims

A method for detecting and monitoring diseases, comprising:

obtaining imaging data of a region of the retina;
identifying boundaries between layers of the retina in the region of the retina, based on the imaging data;
and
determining, on a location-by-location basis for at least a portion of the region of the retina, a measurement value related to a ratio value between a total backscattered signal intensity of one or more target layers of the retina and a total backscattered signal intensity of one or more reference layers to generate a set of measurement values for locations in the portion of the region of the retina,
wherein the measurement value is generally monotonic with respect to an integrated attenuation value such that the ratio value is used as a proxy measurement for the integrated attenuation value.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/825,286Filed 13 Aug 2015 · continuation

Priority

1 Feb 2013

Published

US 2015/0342451 A13 Dec 2015

Granted

13 Dec 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61B 3/0025
Operational features thereof: characterised by electronic signal processing, e.g. eye models
A61B 3/0058
Characterised by display arrangements: for multiple images
A61B 3/102
Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions: for optical coherence tomography [OCT]
A61B 3/12
Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions: for looking at the eye fundus,…

Family

Application61/759,687Us provisional application · filed 1 Feb 2013

Application14/168,303Parent of this continuation · filed 30 Jan 2014

US 2015/0342451 A1Pre-grant publication · published 3 Dec 2015

US 9,179,834 B2Parent of this continuation

US 2014/0218686 A1Published application

US 9,138,139 B2Related patent

US 9,517,005 B2This patent

From the US filing history. Foreign family members aren’t listed.

Attenuation-based optic neuropathy detection with three-dimensional optical coherence tomography

Life of this patent

Attenuation-based optic neuropathy detection with three-dimensional optical coherence tomography

Life of this patent

Abstract

Claims31