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US 9,493,455 B2Granted
Azaindole derivatives as inhibitors of protein kinases
AssigneeOribase Pharma
InventorsGwénaël Cheve, Bénédicte Dayde-Cazals, Bénédicte Fauvel, Cédric Bories, Abdelaziz Yasri
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Abstract
The present invention relates to compounds of the following formula (I) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. The subject matter of the present invention thus also includes the preparation of compounds of formula (I), their uses, in particular in the inhibition of protein kinases which are implicated for example in numerous diseases such as cancers or immune system disorders.
Claims18
Compound of the following formula (I):
- characterized in that,
- R1 is a C1-C6 alkyl group,
- X is CH2 or C═O,
- R2 is hydrogen atom, an alkyl group or a halogen atom,
- Y is chosen from a group consisting of HNC(O), HNC(S), HNSO2, HNC(O)CH2, HNC(O)NH, HNC(S)NH, C(O)NH, C(O)NHCH2, CH2NHC(O) and CH2NHC(S), and
- R3 is chosen from a group consisting of:
- a phenyl group mono or polysubstituted with:
- a hydroxyl,
- a halogen,
- a C1-C6 alkyl-amine,
- a C1-C6 alkoxy,
- a C1-C6 trifluoroalkoxy,
- a C1-C6 alkyl,
- a C1-C6 trifluoroalkyl,
- a heteroaryl fragment optionally substituted with a C1-C6 alkyl, a C1-C6 trifluoroalkyl, a halogen and/or a hydroxyl, wherein said heteroaryl fragment is chosen from a group consisting of dihydrobenzofuran, indol, benzodioxol, benzotriazol, pyridine or a thiazol,
- an imidazole, with the proviso that Y is HNC(S), HNSO2, HNC(O)CH2, HNC(O)NH, HNC(S)NH, C(O)NHCH2, CH2NHC(O), CH2NHC(S) or C(O)NH wherein NH is directly linked to R3,
- a heteroaryl group,
- non aromatic monosubstituted cyclic group, and
- a fragment chosen from a group consisting of:
- and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof.
17 more elements
Dependencies are inferred from the claim text.