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US 9,492,500 B2Granted
Microcin and uses thereof
AssigneeWashington State University
InventorsDouglas R. Call, Lauren Eberhart, Kelly A. Brayton, Thomas E. Besser, Ashish Sawant, Lisa Orfe
Life of this patent
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Abstract
Microcin MccPDI and bacteria harboring the mcpM gene which encodes MccPDI, limit growth of and/or kill pathogenic bacteria such as pathogenic Escherichia coli (E. coli) and/or Shigella bacteria via proximity-dependent inhibition (PDl).
Claims8
A method of killing or decreasing adverse effects of pathogenic Escherichia coli (E. coli) and/or Shigella bacteria, comprising
- identifying a surface or subject known to or suspected of contamination with said pathogenic E. coli and/or Shigella bacteria;
- and
- contacting said pathogenic E. coli and/or Shigella bacteria with
- microcin MccPDI having SEQ ID NO:
- 24 or a functional variant thereof, or
- an organism that produces MccPDI SEQ ID NO:
- 24 or a functional variant thereof,
- wherein said functional variant has a sequence at least 95% identical to SEQ ID NO:
- 24.
6 more elements
Dependencies are inferred from the claim text.