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US 9,434,975 B2Granted
Fluorogenic or fluorophoric compounds and uses thereof
Assignee3M Innovative Properties Company
InventorsStephen B. Roscoe, Shih-Hung Chou, Stephanie J. Moeller, Jesse D. Miller, Kurt J. Halverson, Jason W. Bjork
Life of this patent
Estimating the term…
Abstract
Compounds are provided that are either fluorogenic or fluorophoric. Compositions and articles that include the compounds are also provided. Additionally, methods of detecting a microorganism using the compounds are provided. The compounds are fluorinated and can be used advantageously under acidic conditions.
Claims17
A compound of Formula (I)
- wherein
- R1 is —(CO)—OR3, —(CO)—NR4R5, heterocyclic group, aryl, aralkyl, or cyano;
- R2 is an enzyme-labile group;
- R3 is alkyl, alkenyl, aryl, or aralkyl;
- R4 and R5 are each independently hydrogen, alkyl, aryl, or aralkyl;
- and
- either (a) X1 is hydrogen and X2 is fluoro or (b) X1 is fluoro and X2 is hydrogen, and wherein R2 is a sugar group, sugar acid group, amino sugar group, carboxyl-terminated amino acid group, carboxyl-terminated peptide group, ester group, ester-containing group, phosphate group, or sulfate group;
- and wherein either
- R2 is a sugar group that is a monosaccaride group or a disaccharide group, or
- R1 is —(CO)—OR3 where R3 is alkyl, or
- R2 is a sugar group that is a monosaccaride group or a disaccharide group and R1 is —(CO)—OR3 where R3 is alkyl.
8 more elements
A composition comprising a mixture of a compound of Formula (I-1) and a compound of Formula (I-2);
- wherein
- R1 is —(CO)—OR3, —(CO)—NR4R5, heterocyclic group, aryl, aralkyl, or cyano;
- R2 is hydroxyl or an enzyme-labile group;
- R3 is alkyl, alkenyl, aryl, or aralkyl;
- and
- R4 and R5 are each independently hydrogen, alkyl, aryl, or aralkyl.
3 more elements
Dependencies are inferred from the claim text.