Double-stranded and single-stranded RNA molecules with 5′ Triphosphates and their use for inducing interferon
AssigneeCity of Hope
InventorsJohn J. Rossi, Dongho Kim, Patric Lundberg, Edouard Cantin
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Abstract
Double-stranded and single-stranded RNA molecules, and their use in methods for inducing interferon are provided. The interferon induction provides anti-viral and other medically useful effects, such as anti-cancer effects. Also provided are methods for reducing or inhibiting interferon induction exhibited by such molecules, particularly siRNA and shRNA molecules produced in vitro.
Claims3
A method of inducing an anti-cancer response in a mammalian cell, comprising introducing into a mammalian cell an effective amount of a siRNA molecule, wherein the siRNA molecule is double stranded, wherein the siRNA molecule has a 5′-triphosphate on each strand, wherein the siRNA molecule is targeted to a cancer gene, wherein the siRNA molecule induces interferon which mediates an anti-cancer response and wherein the siRNA molecule reduces expression of the targeted cancer gene.
Dependencies are inferred from the claim text.