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AssigneeShanghai Genechem Co., Ltd.
InventorsYueqiong Cao, Dalong Lv, Xiangying Zhu, Haixiong Han, Honghua Qu, Yangsheng Jin
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The present invention discloses uses of the human ZFX gene and drugs associated therewith. Also disclosed are uses of the human ZFX gene in tumor treatment, tumor diagnosis, and drug preparation. Further disclosed are small interfering RNA (siRNA), and nucleic acid and lentivirus encoding the siRNA to the human ZFX gene and uses thereof. The siRNA and nucleic acid and lentivirus encoding the siRNA provided by the present invention can specifically inhibit the expression of human ZFX gene. Lentiviruses in particular can efficiently infect target cells, inhibit ZFX expression in target cells, and inhibit the growth of tumor cells, thus promote tumor apoptosis and have great significance in tumor treatment.
A method for inhibiting or attenuating the growth, proliferation, and/or survival of a tumor cell, which method comprises administering to the tumor cell a nucleic acid that specifically inhibits transcription or translation of a zinc finger protein X-linked (ZFX) gene, or expression of the ZFX protein, thereby inhibiting the growth, proliferation, and/or survival of the tumor cell.
A method for treating tumor in a subject, which method comprises administering an effective amount of a pharmaceutical composition to the subject, wherein the pharmaceutical composition comprises an oligonucleotide that attenuates the expression of a zinc finger protein X-linked (ZFX) gene in a tumor cell, which oligonucleotide comprises:
Dependencies are inferred from the claim text.