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US 9,434,829 B2Granted
Ligand grafted substrates
Assignee3M Innovative Properties Company
InventorsJerald K. Rasmussen, Catherine A. Bothof
Life of this patent
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Abstract
Ligand-functionalized substrates are describe that are useful in selectively binding and removing biological materials from biological samples, and methods for preparing the same.
Claims16
A method for preparing a ligand-functionalized substrate comprising:
- a) providing a base substrate;
- b) providing a coating solution comprising a copolymer of one or more monomer units having a photoinitiator group, one or more monomer units having a crosslinkable functional group, one or more hydrophilic monomer units, and optionally one or more “other” monomer units;
- c) coating the base substrate with the coating solution;
- d) crosslinking the coating to produce a crosslinked copolymer;
- e) imbibing the substrate bearing the crosslinked copolymer with a solution or suspension comprising (a) one or more ligand functional monomers, (b) optionally one or more hydrophilic monomers;
- and optionally c) one or more “other” monomers;
- f) exposing the imbibed base substrate to UV radiation so as to generate free radicals from the photoinitiator groups of the copolymer, and
- g) graft-polymerizing the monomers of step e) onto the surface of the base substrate.
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A ligand-functionalized substrate represented by the formula:
- where
- MPI* represents the residue of the MPI monomer units having “f” polymerized monomer units, where f is at least one,
- Mcrosslink represent the monomer units derived from the MFG monomer units, having been subsequently crosslinked, and having “g” polymerized monomer units, where g is at least one and (MFG)m are crosslinkable monomer units;
- MHydrophil represents hydrophilic monomer units having “h” polymerized monomer units, where h may be zero;
- MLigand represents ligand monomer units having “j” polymerized monomer units, where “j” is at least 1
- Mother represents other (meth)acryloyl monomer units, where “i” may be zero.
3 more elements
Dependencies are inferred from the claim text.