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US 9,434,825 B2Granted
Nucleophilic high molecular weight polymer functionalization through alkylation
AssigneeSeeo, Inc.
InventorsKulandaivelu Sivanandan, Hany Basam Eitouni, Russell Clayton Pratt, Jonathan C. Pistorino
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Abstract
A new and efficient method of functionalizing high molecular weight polymers through alkylation using a metal hetero alkylbase is described. This novel procedure can also be used to synthesize polymer-based macro-initiators containing radical initiating groups at the chain-ends for synthesis of block copolymers.
Claims11
A method of functionalizing a nucleophilic high molecular weight polymer comprising the steps of:
- a. dissolving the nucleophilic high molecular weight polymer in a first solvent and reacting with a metal hetero alkyl (MHTA) base, to form a first solution;
- b. mixing RZ with the first solution to form a second solution, wherein R is an alkyl group and Z is a leaving group;
- c. mixing the second solution with a second solvent to form a third solution, wherein the second solvent dissolves the MHTA, the RZ, and any reaction byproducts from steps a and b;
- and
- d. precipitating a functionalized high molecular weight polymer from the third solution.
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A method of functionalizing a nucleophilic high molecular weight polymer comprising the steps of:
- a. dissolving the nucleophilic high molecular weight polymer in a first solvent and reacting with metal hetero alkyl (MHTA) base, to form a first solution;
- b. mixing RZ with the first solution to form a second solution;
- c. mixing the second solution with a second solvent to form a third solution, wherein the second solvent dissolves the MHTA, the RZ, and any reaction byproducts from steps a and b;
- and
- d. precipitating a functionalized high molecular weight polymer from the third solution;
- wherein the RZ is an alkyl halide comprising a functional group selected from the group consisting of photoactive groups, electroactive groups, controlled radical polymerization initiators, monomers, reactive alkenes/olefins, click functionalities, and biochemical groups for conjugation to biological molecules.
3 more elements
Dependencies are inferred from the claim text.