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US 9,434,783 B2Granted
Shortened CD95-Fc variant fusion proteins, nucleic acids and host cells thereof
AssigneeApogenix AG
InventorsOliver Hill, Christian Gieffers, Meinolf Thiemann
Life of this patent
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Abstract
The present invention relates to an isolated fusion protein comprising an extracellular CD95 domain or a functional fragment thereof and an Fc domain or functional fragment thereof, formulations providing such fusion protein in a stable form as well as a method for producing such a fusion protein.
Claims26
A fusion protein comprising (i) at least a functional fragment of an N-terminally truncated extracellular cluster of differentiation 95 (CD95) domain, wherein the functional fragment of the N-terminally truncated extracellular CD95 domain consists of the amino acid sequence of SEQ ID NO:
- 11 or 12, or a sequence having at least 97% identity to SEQ ID NO:
- 11 or 12, and (ii) at least an Fc domain or a functional fragment thereof, wherein the Fc domain is a human Fc domain consisting of the amino acid sequence of SEQ ID NO:
- 8 or a sequence having at least 97% identity to SEQ ID NO:
- 8.
1 more element
Dependencies are inferred from the claim text.