Shigella-derived vector and methods of using the same
AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorAnthony T. Maurelli
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Abstract
Recombinant vectors comprising the cell entry region of the Shigella ox EIEC invasion plasmid are provided, as well as, Shigella or EIEC strains comprising the recombinant vectors. The vectors provide an improved platform for developing attenuated vaccine strains of Shigella or EiEC and for delivering other foreign proteins of interest. The recombinant vectors and bacterial strains comprising the same may be used in methods of inducing an immune response.
Claims17
A recombinant vector comprising a cell entry region from a Shigella invasion plasmid and a virF gene from a Shigella invasion plasmid,
- wherein the recombinant vector has no more than about 30-50 kilobase pairs of a Shigella invasion plasmid, and
- wherein the cell entry region comprises an ipa gene locus, an ipg gene locus, a virB gene, and a mxi-spa gene locus.
Dependencies are inferred from the claim text.