Viruses lacking epithelial cell receptor entry
AssigneeMayo Foundation for Medical Education and Research
InventorsRoberto Cattaneo, Vincent H. J. Leonard
Life of this patent
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Abstract
The document provides nucleic acids, polypeptides, and viruses containing nucleic acids and/or polypeptides. The document also provides methods for using viruses to treat cancer patients. Specifically, the document provides nucleic acid molecules encoding viral hemagglutinin (H) polypeptides, viral H polypeptides, and viruses containing nucleic acids and/or H polypeptides. Such viruses are useful for vaccinations and for treating cancer patients as the viruses are not shed.
Claims12
An isolated nucleic acid molecule, wherein said nucleic acid molecule encodes a polypeptide comprising a hemagglutinin (H) polypeptide amino acid sequence that aligns with and has at least 85 percent identity to the amino acid sequence set forth in SEQ ID NO:
- 1, wherein said H amino acid sequence comprises an amino acid other than leucine at the position aligning with position 482 of said amino acid sequence, wherein said amino acid other than leucine is serine.
Dependencies are inferred from the claim text.