Indazole derivatives

A compound of Formula 1,

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is hydrogen;
• R2 is selected from hydrogen, —OH, chloro, fluoro, —CN, methyl, and hydroxymethyl;
• R3 is selected from C6-14 aryl, C1-9 heteroaryl, and C2-6 heterocyclyl, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, R7, and R8;
• R4 is hydrogen;
• R5 is C1-3 haloalkyl;
• R6 is selected from hydrogen, —OH, —NH2, chloro, fluoro, and methyl;
• each R7 is independently selected from —OR9, —N(R9)R10, —NR9C(O)R10, —NHC(O)NR9R10, —NR9C(O)NHR10, —C(O)R9, —C(O)OR9, —C(O)N(R9)R10, —C(O)N(R9)OR10, —C(O)N(R9)S(O)2R8, —N(R9)S(O)2R8, —SR9, —S(O)R8, —S(O)2R8, and —S(O)2N(R9)R10;
• each R8 is independently selected from
• (a) C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, and R11;
• and
• (b) C3-8 cycloalkyl-(CH2)m—, C2-6 heterocyclyl-(CH2)m—, C6-14 aryl-(CH2)m—, and C1-9 heteroaryl-(CH2)m—, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, R11, and C1-6 alkyl optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, and R11;
• each R9 and R10 is independently selected from
• (a) hydrogen;
• (b) C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, and R11;
• and
• (c) C3-8 cycloalkyl-(CH2)m—, C2-6 heterocyclyl-(CH2)m—, C6-14 aryl-(CH2)m—, and C1-9 heteroaryl-(CH2)m—, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, R11, and C1-6 alkyl optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, and R11;
• each R11 is independently selected from —OR12, —N(R12)R13, —N(R12)C(O)R13, —NHC(O)NR12R13, —NR12C(O)NHR13, —C(O)R12, —C(O)OR12, —C(O)N(R12)R13, —C(O)N(R12)OR13, —C(O)N(R12)S(O)2R14, —NR12S(O)2R14, —SR12, —S(O)R14, —S(O)2R14, and —S(O)2N(R12)R13;
• each R12 and R13 is independently selected from
• (a) hydrogen;
• and
• (b) C1-6 alkyl and C3-8 cycloalkyl-(CH2)m—, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, —OH, and —NH2;
• each R14 is independently selected from C1-6 alkyl and C3-8 cycloalkyl-(CH2)m—, each optionally substituted with from one to five substituents independently selected from halo, oxo, —CN, —OH, and —NH2;
• and
• each m is independently selected from 0, 1, 2, 3, and 4;
• wherein each heteroaryl and heterocyclyl moiety has from one to four heteroatoms independently selected from N, O, and S.