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US 9,434,731 B2Granted
Imidazo-, pyrazolopyrazines and imidazotriazines and their use
AssigneeBayer Intellectual Property GmbH
InventorsStephan Siegel, Andreas Wilmen, Susanne Röhrig, Niels Svenstrup, Mark Jean Gnoth, Stefan Heitmeier, Ulrich Rester, Adrian Tersteegen, Michael Gerisch
Life of this patent
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Abstract
The invention relates to substituted imidazo-, pyrazolopyrazines and imidazotriazines and processes for their preparation, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, in particular of hematological disorders, preferably of leukopenias and neutropenias.
Claims3
A compound of the formula
- in which
- U represents CH,
- represents CR12,
- W represents N,
- A represents CR15,
- where
- R12 represents hydroxycarbonyl, C1-C4-alkoxycarbonyl, or —CH2R13,
- and
- where
- R13 represents morpholinyl,
- R15 represents hydrogen,
- R1 represents a group of the formula
- where
- * is the point of attachment to the heterocycle, and
- R3 represents 2-pyridyl, 1,3-thiazol-2-yl, 1,3-thiazol-4-yl, or 1H-1,2,4-triazol-5-yl,
- where 2-pyridyl, 1,3-thiazol-2-yl and 1,3-thiazol-4-yl are substituted by 1 or 2 substituents, where the substituents independently of one another are selected from the group consisting of halogen, cyano, nitro, amino, trifluoromethyl, trifluoromethoxy, aminocarbonyl, trifluoromethylcarbonyl, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylamino, C3-C4-cycloalkylamino, C1-C4-alkylcarbonyl, C1-C4-alkoxycarbonyl, C1-C4-alkylaminocarbonyl and C3-C6-cycloalkylcarbonyl,
- where alkyl, alkoxy, alkylamino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl and cycloalkylcarbonyl may be substituted by a substituent, where the substituent is selected from the group consisting of halogen, cyano, hydroxyl, amino, trifluoromethyl and C3-C6-cycloalkyl,
- and
- where 1H-1,2,4-triazol-5-yl, may be substituted by a substituent, where the substituent is selected from the group consisting of halogen, cyano, nitro, amino, trifluoromethyl, trifluoromethoxy, aminocarbonyl, trifluoromethylcarbonyl, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylamino, C3-C4-cycloalkylamino, C1-C4-alkoxycarbonyl, C1-C4-alkylaminocarbonyl and C3-C6-cycloalkylcarbonyl,
- R2 represents phenyl,
- where phenyl may be substituted by 1 to 3 halogen substituents,
- or one of its salts.
19 more elements
Dependencies are inferred from the claim text.