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US 9,434,728 B1Granted
Nitrogen containing compounds and their use
AssigneeWockhardt Limited
InventorsPrasad Keshav Deshpande, Shivaji Sampatrao Pawar, Satish Bhawsar, Ravindra Dattatraya Yeole, Sachin Bhagwat, Mahesh Vithalbhai Patel
Life of this patent
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Abstract
Compound of Formula (I), its preparation and use in preventing or treating bacterial infection is disclosed. Formula (I)
Claims18
A compound of Formula (I):
- or a stereoisomer or a pharmaceutically acceptable derivative thereof;
- wherein M is a cation.
A process for preparation of (2S, 5R)-6-sulfooxy-2-(aminomethyl)-7-oxo-1,6-diaza-bicyclo [3.2.1]octane of Formula (XI), wherein the process comprising:
- (a) Converting a compound of Formula (II) to a compound of Formula (III);
- (b) Reacting a compound of Formula (III) with p-nitrophenyl sulfonyl chloride in presence of a base to obtain a compound of Formula (IV);
- (c) Reacting a compound of Formula (IV) with sodium azide to obtain a compound of Formula (V);
- (d) Converting a compound of Formula (V) to a compound of Formula (VI);
- (e) Hydrogenolysis of a compound of Formula (VI) to obtain a compound of Formula (VII);
- (f) Reacting a compound of Formula (VII) with sulfonating agent, followed by a reaction with tetrabutyl ammonium hydrogen sulfate to obtain a compound of Formula (VIII);
- (g) Converting a compound of Formula (VIII) to a compound of Formula (IX);
- (h) Reacting a compound of Formula (IX) with trifluoroacetic acid in suitable solvent to obtain a compound of Formula (X);
- and
- (i) Converting a compound of Formula (X) to a compound of Formula (XI).
7 more elements
Dependencies are inferred from the claim text.