5-azaindazole compounds and methods of use

A compound selected from Formula I:

• and stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein:
• R1 is a five-membered or six-membered heteroaryl selected from the group consisting of:
• where the wavy line indicates the point of attachment
• R3 is selected from H, —CH3, —CH2CH3, —CH(CH3)2, —C(CH3)3, —CH2CH(CH3)2, —CH2NH2, —CH2NHCH3, —CH2CH2NH2, —CH2CH2CH2NH2, —CH2CH(CH3)NH2, —CH2OH, —CH2CH2OH, —C(CH3)2OH, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CN, —CF3, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CON(CH3)2, —C(CH3)2CONH2, —S(O)2N(CH3)2, —SCH3, —CH2OCH3, —S(O)2CH3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, and oxetanyl;
• R4 is independently selected from F, Cl, Br, I, —CH3, —CH2CH3, —CH(CH3)2, —C(CH3)3, —CH2CH(CH3)2, —CH2NH2, —CH2NHCH3, —CH2CH2NH2, —CH2CH2CH2NH2,—CH2CH(CH3)NH2, —CH2OH, —CH2CH2OH, —C(CH3)2OH, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CN, —CHF2, —CF3, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CON(CH3)2, —C(CH3)2CONH2, —NO2, —NH2, —NHCH3, —N(CH3)2, —NHCH2CHF2, —NHCH2CF3, —NHCOCH3, —N(CH3)COCH3, —NHC(O)OCH2CH3, —NHC(O)OCH2Cl3, —NHC(O)OC6H5, —NHS(O)2CH3, —N(CH3)C(CH3)2CONH2, —N(CH3)CH2CH2S(O)2CH3, ═O, —OH, —OCH3, —OCH2CH3, —S(O)2N(CH3)2, —SCH3, —CH2OCH3, —S(O)2CH3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholino;
• and
• n is 0, 1, 2, or 3;
• R2 is a six-membered heteroaryl, having the structure:
• where the wavy line indicates the point of attachment;
• Xa is N or CRa;
• Xb is N or CRb;
• Xc is N or CRc;
• Xd is N or CRd;
• where 0 or 1 of Xa, Xb, Xc, and Xd is N;
• Ra, Rb, Rc and Rd are independently selected from H, F, Cl, Br, I, —CH3, —CH2CH3, —CH(CH3)2, —C(CH3)3, —CH2CH(CH3)2, —CH2NH2, —CH2NHCH3, —CH2CH2NH2, —CH2CH2CH2NH2, —CH2CH(CH3)NH2, —CH2OH, —CH2CH2OH, —C(CH3)2OH, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CN, —CHF2, —CF3, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CON(CH3)2, —C(CH3)2CONH2, —NO2, —NH2, —NHCH3, —N(CH3)2, —NHCH2CHF2, —NHCH2F3, —NHCOCH3, —N(CH3)COCH3, —NHCH(O)OCH2CH3, —NHC(O)OCH2Cl3, —NHC(O)(OC6H5, —NHS(O)2CH3, —N(CH3)C(CH3)2CONH2, —N(CH3)CH2CH2S(O)2CH3, ═O, —OH, —OCH3, —OCH2CH3, —S(O)2N(CH3)2, —SCH3, —CH2OCH3, —S(O)2CH3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholine;
• and, wherein at least one of Ra, Rb, Rc and Rd is independently selected from a 3-7 member monocyclic heterocyclyl, having 1 or 2 N, and a 7-10 member bicyclic heterocyclyl, having 1 or 2 N, the other of Ra, Rb, Rc and Rd are as described above, wherein said heterocyclyl is optionally substituted with one or more groups independently selected from F, Cl, Br, I, —CH3, —CH2CH3, —CH(CH3)2, —C(CH3)3, —CH2CH(CH3)2, —CH2NH2, —CH2NHCH3, —CH2CH2NH2, —CH2CH2CH2NH2, —CH2CH(CH3)NH2, —CH2OH, —CH2CH2OH, —C(CH3)20H, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CN, —CHF2, —CF3, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CON(CH3)2, —C(CH3)2CONH2, —NO2, —NH2, —NHCH3, —N(CH3)2, —NHCH2CHF2, —NHCH2F3, —NHCOCH3, —N(CH3)COCH3, —NHCH(O)OCH2CH3, —NHC(O)OCH2Cl3, —NHC(O)OC6H5, —NHS(O)2CH3, —N(CH3)C(CH3)2CONH2, —N(CH3)CH2CH2S(O)2CH3, ═O, —OH, —OCH3, —OCH2CH3, —S(O)2N(CH3)2, —SCH3, —CH2OCH3, —S(O)2CH3, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, azetidinyl, azepanyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, (piperidin-4-yl)ethyl), pyranyl, (piperidin-4-ylmethyl), morpholinomethyl, and morpholine.