TOFA analogs useful in treating dermatological disorders or conditions

A compound of formula (I):

• wherein:
• R1 is —O—R3—OR2, —O—R3—OC(O)—N(R5)R6, —O—R3—N(R4)C(O)OR5, —O—R3—C(O)OR5, —O—R3—C(O)N(R5)R6 or —N(R5)S(O)2—R4;
• each R2 is independently alkyl, haloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl;
• each R3 is independently an optionally substituted alkylene chain;
• and
• R4 is optionally substituted alkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl or optionally substituted heteroarylalkyl;
• each R5 is independently hydrogen, alkyl, optionally substituted cycloalkyl, optionally substituted aryl or optionally substituted aralkyl;
• and
• each R6 is alkyl, optionally substituted cycloalkyl, optionally substituted aralkyl or —R3—C(O)OR4;
• or any R5 and R6, together with the nitrogen to which they are both attached, form an optionally substituted N-heterocyclyl or an optionally substituted N-heteroaryl;
• wherein, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted alkylene chain;
• optionally substituted cycloalkyl, optionally substituted N-heterocyclyl or optionally substituted N-heteroaryl may comprise one or more substituents selected from the group consisting of alkyl, akenyl, halo, haloalkyl, haloalkenyl, cyano, nitro, aryl, aralkyl, heteroaryl, heteroarylalkyl,
• —R15—OR14, —R15—OC(O)—R14, —R15—N(R14)2, —R15—C(O)R14, —R15—C(O)OR14, —R15—C(O)N(R14)2, —R15—N(R14)C(O)OR16, —R15—N(R14)C(O)R16, —R15—N(R14)S(O)tR16 (where t is 1 to 2), —R15—N═C(OR14)R14, —R15S(O)tOR16 (where t is 1 to 2), —R15—S(O)pR16 (where p is 0 to 2), and —R15—S(O)tN(R14)2 (where t is 1 to 2) wherein each R14 is independently hydrogen, alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl;
• each R15 is independently a direct bond or a straight or branched alkylene or alkenylene chain;
• and each R16 is alkyl, haloalkyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heterocyclyl, heterocyclylalkyl, heteroaryl or heteroarylalkyl,
• as a single stereoisomer or as a mixture thereof;
• or a pharmaceutically acceptable salt thereof.