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US 9,434,715 B2Granted
Benzoimidazol-2-yl pyrimidine modulators of the histamine H4 receptor
AssigneeJanssen Pharmaceutica NV
InventorsMatteo Conza, Magali B. Hickey, Stefan Horns, Susanne Lochner
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Abstract
Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.
Claims3
A method of obtaining a purified pharmaceutically acceptable salt of a [5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine, comprising:
- forming a hemitartrate salt of the compound of formula (2):
- in water to yield an aqueous hemitartrate salt solution;
- seeding said aqueous solution with crystal seeds of the tetrahydrate of said hemitartrate to obtain a seeded aqueous solution;
- and
- crystallizing out of said seeded aqueous solution the solid tetrahydrate hemitartrate of formula (3):
2 more elements
Dependencies are inferred from the claim text.