US 9,434,704 B2 · Compositions and methods for the treatment of neurological degenerative disorders

Abstract

The invention relates to the compounds of formula I and formula II or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I or formula II; and methods for treating or preventing neurological degenerative disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of Parkinson's disease (PD), restless legs syndrome (RLS), cluster headache, depression, fibromyalgia, sexual dysfunction, amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease and depression.

Claims20

Dependent claims

A compound of Formula I:

or pharmaceutically acceptable salts, stereoisomers, enantiomers, hydrates, solvates, or mixtures thereof, wherein:
R1 represents
R2 represents H, D,
a is independently 2, 3 or 7;
each b is independently 3, 5 or 6;
e is independently 1, 2 or 6;
c and d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3;
R3 represents
R4 represents
a is independently 2, 3 or 7;
each b is independently 3, 5 or 6;
e is independently 1, 2 or 6;
and
c and d are each independently H, D, —OH, —OD, C1-C6-alkyl, —NH2 or —COCH3;
and wherein when R2 is H, R1 may be NULL.

12 more elements

Dependencies are inferred from the claim text.

Facts

Application

14/399,528Filed 2 Feb 2013

Priority

IN 1808/CHE/20128 May 2012

Published

US 2015/0111932 A123 Apr 2015

Granted

6 Sep 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

C07D 277/82
With hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals,…:…
A61K 31/428
Thiazoles: condensed with carbocyclic rings
A61K 47/12
Containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides: carboxylic acids; Salts or anhydrides thereof
A61K 47/14
Containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides: esters of carboxylic acids, e.g. fatty acid monoglycerides,…

Compositions and methods for the treatment of neurological degenerative disorders

Life of this patent

Compositions and methods for the treatment of neurological degenerative disorders

Life of this patent

Abstract

Claims20