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US 9,434,693 B2Granted
Substituted pyrazoles as N-type calcium channel blockers
AssigneeJanssen Pharmaceutica NV
InventorsMark Wall, Nalin Subasinghe, Zhihua Sui, Christopher Flores
Life of this patent
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Abstract
Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, ring A, and G are defined herein.
Claims20
A compound of Formula (I)
- wherein
- R1 is selected from the group consisting of C1-4alkyl, C1-4alkoxy, di(C1-4alkyl)amino, chloro, trifluoromethoxy, trifluoromethyl, and cyano;
- ring A is phenyl or a heteroaryl selected from the group consisting of pyridinyl, thienyl, benzofuranyl, quinolinyl, and indolyl;
- R2 is selected from the group consisting of C1-4alkyl, C1-4alkoxy, C1-4alkylthio, cyano, fluoro, chloro, hydroxy, and di(C1-4alkyl)amino;
- G is G1, G2, G3, or G4;
- wherein
- Q is selected from the group consisting of O, S, SO2, N—R4, CH2,CH(R5), CF2, C(CH3)2, C(O), and a spirofused
- W is selected from the group consisting of O, S, CH(OH), C(O), S(O), SO2, and N—R4;
- R3 and R4 are each independently selected from the group consisting of 2,2,2-trifluoroethyl, di(C1-4alkyl)aminocarbonyl, N-methoxy-N-methylaminocarbonyl, phenylcarbonyl, C1-4alkylcarbonyl, trifluoromethylcarbonyl, C1-4alkoxycarbonyl, C3-7cycloalkylsulfonyl, trifluoromethylsulfonyl, and 3,5-dimethylisoxazol-4-ylsulfonyl;
- R5 is trifluoromethylcarbonylamino, amino, or C1-4alkoxycarbonylamino;
- and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.
8 more elements
Dependencies are inferred from the claim text.