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US 9,434,687 B2Granted
Detection of synthetic cannabinoids
AssigneeRandox Laboratories Limited
InventorsElouard Benchikh, Stephen Peter FitzGerald, Paul John Innocenzi, Philip Andrew Lowry, Ivan Robert McConnell
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Abstract
The invention describes methods and kits for detecting and determining current and future synthetic cannabinoids from the JWH and CP families. Unique antibodies derived from novel immunogens enable said methods and kits.
Claims1
An antibody that binds to structure:
- wherein
- R4,1 is a C4 or C5, substituted or unsubstituted, saturated or unsaturated, hydrocarbon chain;
- and,
- Y is substituted or unsubstituted naphthyl or substituted phenyl;
- and,
- wherein the antibody has a cross-reactivity presented as B/B0% of ≦15% (standardised with JWH-018 and using tracer ESC5913,
- wherein JWH-018 is
- wherein ESC5913 is
- and
- wherein HRP is Horse Radish Peroxidase)
- against each one of the cross-reactants selected from the group consisting of JWH-018, JWH-018 (N-(3-methylbutyl) isomer, JWH-073, JWH-073 4-methylnaphthyl analogue, JWH-022, JWH-081, JWH-081 5-methoxynaphthyl isomer, JWH-122, JWH-122 6-methylnaphthyl isomer, JWH-122 7-methylnaphthyl isomer, JWH-182, JWH-210, JWH-398, JWH-398 5-chloronaphthyl isomer, AM-694, AM-2201, and AM-2201 N-(4-fluoropentyl) isomer,
- at a cross-reactant concentration of 100 ng/ml,
- wherein B0 is absorbance at 450 nm at zero ng/ml standard concentration, and
- wherein B is absorbance at 450 nm at predetermined standard concentrations.
11 more elements
Dependencies are inferred from the claim text.