Macromolecules for treating atherosclerosis

A compound of formula II:

• A-(CH(OC(═O)R3))n—W—W1—R2 II
• wherein;
• A is selected from carboxy, —SO3H and —PO3H;
• n is independently 2, 3, 4, 5 or 6;
• W is —C(═O)—, —C(═S)—, or is absent;
• W1 is O, S or NH;
• each R1 is independently a hydrophobic chain;
• R2 is a polyether, wherein the polyether has the following structure:
• R5—(R6—O—)a—R6—
• wherein R5 is a 1 to 20 carbon straight-chain or branched alkyl group, —OH, —OR7, —NH2, —NHR7, —NHR7R8, —CO2H, —SO3H (sulfo), —CH2—OH, —CH2—OR7, —CH2—O—CH2—R7, —CH2—NH2, —CH2—NHR7, —CH2—NR7R8, —CH2CO2H, —CH2SO3H, or —O—C(═O)—CH2—CH2—C(═O)—O—;
• R6 is a 1 to 10 carbon straight-chain or branched divalent alkylene group;
• each R7 and R8 is independently a 1 to 6 carbon straight-chain or branched alkylene group;
• and
• a is an integer from 2 to 150, inclusive;
• and
• each R3 is independently (C1-C8)alkyl wherein each (C1-C8)alkyl is independently substituted with one or more —O(C═O)R1 groups;
• or a salt thereof.