Method for dermal regeneration by administering an ether cross-linked glucomannan/hyaluronic acid composition

A method for treating a condition of skin of a mammalian subject in need of such treatment by promoting an accumulation of fibroblasts in the skin and increasing production of collagen in skin, the method comprising delivering to the skin of the subject an active component comprising:

• a glucomannan polysaccharide cross linked with hyaluronic acid, or an oligosaccharide derived from glucomannan cross linked with hyaluronic acid, or mixtures or combinations thereof;
• wherein the glucomannan polysaccharide or the oligosaccharide derived from glucomannan is derived from konjac root (Amorphophallus konjac);
• wherein the glucomannan polysaccharide or the oligosaccharide derived from glucomannan is cross-linked with the hyaluronic acid by ether bonds using a bifunctional epoxide or a polyfunctional epoxide cross-linking agent;
• wherein the active component is formulated as a gel, or with an encapsulation vehicle, liposome, or particulate or microfine vehicle, and
• wherein the treating is selected from the group consisting of regenerating, healing, augmenting, reducing scarring, reducing signs of ageing, heals wounds or ulcers, regenerating atrophic skin due to trauma, skin disease or skin ageing, smoothing wrinkles, increasing skin firmness, and increasing elasticity in ageing skin.