Method, device and system for modulating an activity of brown adipose tissue in a vertebrate subject

A system for controllable cooling comprising:

• a cooling device including
• one or more cooling elements configured to be applied to one or more tissues of a vertebrate subject to modulate at least one activity of brown adipose tissue of the vertebrate subject, wherein at least a portion of the one or more cooling elements is configured to be implantable;
• and
• a programmable controller operably coupled to the one or more cooling elements and configured to provide instructions to the one or more cooling elements in response to information regarding at least one of a number of calories ingested by the vertebrate subject or a type and quantity of food ingested by the vertebrate subject;
• and
• a user interface configured to transmit to the programmable controller of the cooling device the information regarding the at least one of the number of calories ingested by the vertebrate subject or the type and the quantity of food ingested by the vertebrate subject.