Interventional medical device and manufacturing method thereof

A method for preparing an interventional medical device, wherein said method comprises:

• preparing a microporous structure on the surface of the stent body;
• formulating a solution containing at least one drug for suppressing proliferation of adventitial fibroblasts and at least one drug for suppressing proliferation of intimal cells and/or smooth muscle cells, wherein said at least one drug for suppressing adventitial fibroblast proliferation is or includes asiaticoside and said at least one drug for suppressing proliferation of intimal cells and/or smooth muscle cells is or includes rapamycin,
• loading the drugs within the formulated solution into said microporous structure, wherein the ratio between the weight of asiaticoside and that of rapamycin present in the microporous structure is from 2:1 to 5:1;
• drying the stent body to obtain said interventional medical device.

A method for preparing an interventional medical device, wherein said method comprises:

• formulating a mixed solution of a drug for suppressing adventitial fibroblast proliferation and a polymer, as well as a mixed solution of a drug for suppressing proliferation of intimal cells and/or smooth muscle cells and a polymer, respectively, or formulating a mixed solution of a drug for suppressing adventitial fibroblast proliferation, a drug for suppressing proliferation of intimal cells and/or smooth muscle cells and a polymer, wherein said drug for suppressing adventitial fibroblast proliferation is asiaticoside and said drug for suppressing proliferation of intimal cells and/or smooth muscle cells is rapamycin;
• successively coating the surface of the stent body with the mixed solution of the drug for suppressing adventitial fibroblast proliferation and the polymer, as well as the mixed solution of the drug for suppressing proliferation of intimal cells and/or smooth muscle cells and the polymer, or coating the surface of the stent body with the mixed solution of the drug for suppressing adventitial fibroblast proliferation, the drug for suppressing proliferation of intimal cells and/or smooth muscle cells and the polymer;
• drying the stent body to obtain the interventional medical device, wherein the ratio between the weight of asiaticoside and that of rapamycin present in the interventional medical device is from 2:1 to 5:1.