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US 9,433,699 B2Granted
Hydrogel comprising catechol group-coupled chitosan or polyamine and poloxamer comprising thiol group coupled to end thereof, preparation method thereof, and hemostat using same
AssigneeInnotherapy Inc.
InventorsHaeshin Lee, Moon Sue Lee, Ji Hyun Ryu
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Abstract
The present invention relates to an adhesive hydrogel composition containing catechol group-coupled chitosan and Pluronic comprising a thiol group coupled to the end thereof, and more specifically, to an adhesive composition which is safe in vivo and in vitro, is temperature sensitive, and has an excellent hemostatic effect and thus can be used as a bioadhesive, and a medical adhesive, an adhesion barrier and a surface adsorption inhibitor comprising the same.
Claims16
A temperature sensitive hydrogel composition comprising:
- (i) a chitosan, covalently bound to catechol groups along its backbone;
- and (ii) a poloxamer containing terminal thiol groups, wherein each sulfur from said terminal thiol groups of the poloxamer is bound to a different catechol group, as respective sulfur-bound catechol groups, and wherein each of the sulfur-bound catechol group contains dihydroxy functional groups.
A method for preparing a hydrogel, the method comprising:
- (A) preparing a chitosan, covalently bound to catechol groups along its backbone;
- (B) preparing a poloxamer containing terminal thiol groups;
- (C) preparing a catechol-chitosan solution by dissolving the chitosan, covalently bound to catechol groups along its backbone, in a buffer;
- (D) preparing a thiol-poloxamer solution by dissolving the poloxamer containing terminal thiol groups in a buffer;
- (E) preparing an adhesive hydrogel solution by mixing the catechol-chitosan solution of step (C) with the thiol-poloxamer solution of step (D);
- and
- (F) gelating the adhesive hydrogel solution of step (E).
4 more elements
Dependencies are inferred from the claim text.