Back to results
US 9,433,684 B2Granted
Conjugates of small-interfering nucleic acids
AssigneeNektar Therapeutics
InventorsSamuel P. McManus, Timothy A. Riley, Sean M. Culbertson, Antoni Kozlowski, Dennis G. Fry, Xuejun Yuan, Dawei Sheng, Vidula R. Dixit
Life of this patent
Estimating the term…
Abstract
The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.
Claims10
A conjugate comprising a residue of a siNA having a 5′ amino linker with a terminal amino group having the structure
- covalently attached at the terminal amino group to a single polymeric reagent having the following structure,
- wherein:
- R2 is H and each of R1 and R3 is
- R2 is H and each of R1 and R3 is
- R1 is H, R2 is
- and R3 is
- R1 is H, R2 is
- and R3 is
- where each m-PEG represents CH3O(CH2CH2O)n—CH2CH2˜ and (n) is defined to provide CH3O(CH2CH2O)n—CH2CH2˜ with a weight-average molecular weight of from 10,000 Daltons to 40,000 Daltons
- , and wherein the siNA is selected from the group consisting of double stranded siNA that is blunt ended, double stranded siNA that has a 5′overhang, and double stranded siNA that has a 3′ overhang.
7 more elements
Dependencies are inferred from the claim text.