Use of TRMP8 for treating opthalmic diseases or conditions involving tearing
AssigneesUniversidad Miguel Hernandez De Elche, Consejo Superior De Investigaciones Cientificas (Csic)
InventorsCarlos Belmonte Martínez, Juana Gallar Martínez, Antonio Ferrer Montiel, Asia Fernández Carvajal, Félix Viana de la Iglesia
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Abstract
The invention relates to therapeutic compositions for the treatment of dry eye, more specifically to compositions comprising a TRPM8 receptor agonist ligand. Furthermore, the invention relates to therapeutic compositions for the treatment of epiphora, more specifically to compositions comprising a TRPM8 receptor antagonist.
Claims30
A method for treating an ophthalmic disease or condition, said disease or condition involving tearing and/or relieving symptoms thereof comprising administering a therapeutically effective amount of a composition comprising a molecule binding specifically to the TRPM8(Transient receptor potential cation channel subfamily M member 8) receptor to a subject in need thereof,
- (i) wherein the binding of the molecule to the TRPM8 receptor modulates the activity of the TRPM8 channel;
- (ii) wherein the binding of the molecule to the TRPM8 receptor increases or decreases tear secretion caused by the ophthalmic disease or condition;
- and
- (iii) wherein the amount of the molecule binding specifically to the TRPM8 receptor is not cytotoxic to the subject in need thereof.
Dependencies are inferred from the claim text.