Thermal treatment of a pilosebaceous unit with metal nanoparticles in surfactant containing solutions
AssigneeSienna Biopharmaceuticals, Inc.
InventorsTodd James Harris, Alice Ann Chen Kim
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Abstract
Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of a pilosebaceous unit with metal nanoparticles in surfactant containing solutions are disclosed.
Claims20
A method of localizing thermal damage to a pilosebaceous unit, comprising:
- topically applying a composition comprising a surfactant and nanoparticles to a skin surface;
- wherein the nanoparticles have at least one peak absorption wavelength selected from the group consisting of:
- 755 nm, 800-810 nm, and 1064 nm,
- wherein the nanoparticles are unassembled,
- wherein the nanoparticles are provided in a concentration of 109 to 1016 particles per ml of the composition
- wherein the nanoparticles comprise a conductive metal portion comprising at least one of gold, silver, and platinum,
- wherein the nanoparticles comprise a coating that coats the conductive metal portion;
- targeting a pilosebaceous unit by redistributing a portion of the composition of nanoparticles from the skin surface to the pilosebaceous unit while a remaining portion of the composition is left on the skin surface;
- removing the remaining portion of the composition from the skin surface;
- and
- irradiating the composition of nanoparticles with an energy source to induce a surface plasmon in said nanoparticles, thereby localizing thermal damage to said pilosebaceous unit.
A method of localizing thermal damage to a pilosebaceous unit with a surfactant composition, comprising:
- topically applying a composition comprising nanoparticles and a surfactant to a skin surface,
- wherein the nanoparticles comprise a conductive metal portion comprising at least one of gold, silver, and platinum,
- wherein the nanoparticles comprise a coating that coats the conductive metal portion;
- wherein the nanoparticles are unassembled,
- wherein the nanoparticles are provided in a range of 109 to 1016 particles in the composition;
- distributing a portion of the composition from the skin surface to a portion of a pilosebaceous unit while a remaining portion of the composition is left on the skin surface;
- removing the remaining portion of the composition from the skin surface;
- and
- exposing the composition to an energy wavelength in a range selected from the group consisting of:
- 755 nm, 800-810 nm, and 1064 nm, thereby inducing a surface plasmon in said nanoparticles, thereby localizing thermal damage to said portion of the pilosebaceous unit.
A method of treating a pilosebaceous unit with a surfactant composition, comprising:
- applying a composition comprising a surfactant and nanoparticles to a skin surface,
- wherein the nanoparticles have a concentration of 109 to 1016 particles per ml of the composition, wherein the nanoparticles are unassembled,
- wherein the nanoparticles comprise at least one of gold, silver, and platinum,
- distributing a portion of the composition of from the skin surface to a portion of a pilosebaceous unit while a remaining portion of the composition is left on the skin surface;
- wherein the nanoparticles comprise a coating,
- removing the remaining portion of the composition from the skin surface, and
- exposing the composition of nanoparticles to an energy wavelength, thereby localizing thermal damage to said portion of the pilosebaceous unit.
Dependencies are inferred from the claim text.