Composition comprising a colloidal synthetic bioresorbable vector and a viral vector

A method of vaccination against a viral, bacterial or non-infectious disease comprising administering an effective dose of a prime vaccine and then an effective dose of a boost vaccine, each one of the prime vaccine and the boost vaccine comprising an active principle, wherein:

• the prime vaccine comprises, as the active principle, a colloidal synthetic bioresorbable vector comprising at least one protein substance attached to a synthetic vector by inclusion or bonding;
• and
• the boost vaccine comprises, as the active principle, a viral vector comprising at least one nucleotide sequence which codes for a protein substance corresponding to the at least one protein substance of the colloidal synthetic bioresorbable vector.