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AssigneeMerck Patent GmbH
InventorsMarkus Weigandt, Andrea Hanefeld, Armin Kuebelbeck, Gregor Larbig
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The invention relates to ultrasmall, monodisperse nanoparticles comprising silicon dioxide to the surface of which at least one antigen is attached. The nanoparticles can be used for the immunoprophylaxis or immunotherapy of cancer. The invention also relates to a method for the targeting of antigens at antigen-presenting cells and for the activation of the immune system, where the efficiency of targeting and/or immunoactivation are set via the particle characteristics. The invention also relates to a method for the active and passive immunization of a mammal.
A method for the activation of the immune system of a patient in need thereof and providing an adjuvant immune response, comprising parenterally administering to a patient in need thereof, monodisperse nanoparticles of silicon dioxide, where the nanoparticles have a diameter of 5 to 50 nm and are free of additional adjuvants.
A method for the induction of a T-cell response, antibody response and/or dendritic cell maturation in a mammal, comprising administering an effective amount of a monodispersion of nanoparticles having a diameter of 5 to 50 nm suitable for parenteral administration and a solvent to said mammal,
Dependencies are inferred from the claim text.