Compositions containing broccoli seeds for treatment or preventing prostate cancer

A method for obtaining a sulforaphane-containing composition for the treatment of prostate cancer or its recurrence comprising:

• a. mechanically cold pressing non-sprouted broccoli seeds of the Brassica Oleracea Italica variety to obtain a partially delipidated cake containing glucoraphanin;
• b. obtaining a hydrolysate by enzymatically hydrolyzing the partially delipidated cake to hydrolyze the glucoraphanin into sulforaphane;
• c. adding acetone to the hydrolysate to reduce lipid content and erucic acid content of the hydrolysate to a concentration below 5% by weight;
• d. filtering the hydrolysate to recover a filtrate with a low content of lipids and a concentration below 5% by weight of erucic acid;
• e. evaporating the acetone of the filtrate to recover an aqueous phase;
• f. adding ethyl acetate to the aqueous phase to recover a phase containing the ethyl acetate and sulforaphane;
• g. evaporating the ethyl acetate contained in the phase containing the ethyl acetate and sulforaphane to obtain a non-aqueous extract containing at least 30% by weight of sulforaphane;
• h. drying the non-aqueous extract on a polysaccharide support selected from the group consisting of:
• acacia gum, maltodextrin, and their mixture, to obtain a powder;
• i. incorporating the powder in a polysaccharide matrix selected from the group consisting of:
• acacia gum, maltodextrin, and the mixture thereof, to obtain an encapsulated powder containing at least 10% by weight of sulforaphane
• j. incorporating the encapsulated powder within a pharmaceutical form selected from the group consisting of:
• a capsule, a tablet, a coated pill, and a film-coated tablet;
• said method being performed without a step of aqueous extraction between the step g and the step h.