Amides of acetic and propionic acids
AssigneeBayer Intellectual Property GmbH
InventorsJoachim Luithle, Frank-Gerhard Bob, Christina Erb, Katrin Schnizler, Timo Flessner, Marja V. Kampen, Christoph Methfessel
Life of this patent
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Abstract
The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
Claims12
A method of treating a cognitive impairment in a patient in need thereof, comprising administering to the patient a compound represented by formula (I)
- in which
- R1 is 1-azabicyclo[2.2.2]oct-3-yl optionally substituted by (C1-C6)-alkyl,
- A is methylene or ethylene,
- R2 is benzothiophenyl optionally substituted by radicals selected from the group of halogen, formyl, —CO—NR4R5, —CO—OR6, —NR7R8, —NR9—CO—R10, cyano, trifluoromethyl, trifluoromethoxy, nitro, optionally hydroxyl-, amino-, —NH—CO—R11— or cyano-substituted (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylthio,
- in which R4, R5, R6, R7, R8, R9, R10 and R11 are independently of one another hydrogen, (C1-C6)-alkyl, phenyl or benzyl,
- and
- R3 is hydrogen or (C1-C6)-alkyl,
- or a salt thereof.
A method of treating a cognitive impairment in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising:
- i) a compound represented by formula (I)
- in which
- R1 is 1-azabicyclo[2.2.2]oct-3-yl optionally substituted by (C1-C6)-alkyl,
- A is methylene or ethylene,
- R2 is benzothiophenyl optionally substituted by radicals selected from the group of halogen, formyl, —CO—NR4R5, —CO—OR6, —NR7R8, —NR9—CO—R10, cyano, trifluoromethyl, trifluoromethoxy, nitro, optionally hydroxyl-, amino-, —NH—CO—R11— or cyano-substituted (C1-C6)-alkyl, (C1-C6)-alkoxy, (C1-C6)-alkylthio,
- in which R4, R5, R6, R7, R8, R9, R10 and R11 are independently of one another hydrogen, (C1-C6)-alkyl, phenyl or benzyl,
- and
- R3 is hydrogen or (C1-C6)-alkyl,
- or a salt thereof;
- and
- ii) one or more pharmaceutically acceptable carriers or excipients.
Dependencies are inferred from the claim text.