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US 9,433,608 B2Granted
Compositions and method for treatment of ischemic neuronal reperfusion injury
AssigneeHoward University
InventorsHarpal S. Mangat, Pradeep K. Karla
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Abstract
A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition may include at least a benzodiazepine class material. In another form, the composition may include at least two components selected from the group consisting of an antagonist of the type 3 ryanodine receptor, an NMDA blocker (antagonist), and a benzodiazepine class material which can be administered for ischemic neuronal reperfusion injury. In one form, all three components may be used.
Claims6
A composition comprising:
- an antagonist of a type 3 ryanodine receptor comprising at least one of val-dantrolene, val-val-dantrolene, and combinations thereof;
- and
- at least one additional material selected from the group consisting of an NMDA blocker, a benzodiazepine class material, derivatives thereof, and combinations thereof.
A kit for treatment of neuronal reperfusion injury with ischemic neuropathy comprising:
- an antagonist of a type 3 ryanodine receptor comprising at least one of val-dantrolene, val-val-dantrolene, and combinations thereof;
- and
- at least one additional material selected from the group consisting of an NMDA blocker, a benzodiazepine class material, derivatives thereof, and combinations thereof.
Dependencies are inferred from the claim text.