US 9,433,607 B2 · Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-b]furan-2-carbohydrazide derivatives as an active ingredient

Abstract

The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.

Claims8

Dependent claims

A method of treating cancer, comprising administering a pharmaceutically effective dose of a compound represented by the below formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient to a subject having cancer:

wherein
R1 is
wherein R2 is methyl, R3 is methyl, allyl, cyanomethyl or —CH2(C═O)OCH2CH3, and R4 is nitro, 4-bromophenyl, 2,3-dichlorophenyl, 4-nitrophenyl or 4-methyl-3-nitrophenyl.

Dependencies are inferred from the claim text.

Facts

Application

14/641,065Filed 6 Mar 2015 · continuation in part

Priority

KR 10-2012-00994127 Sep 2012

Published

US 2015/0182502 A12 Jul 2015

Granted

6 Sep 2016

Term ends

Not estimatedThe source records don’t support an estimate.

Classification6 codes

A61K 31/405
Indoles, e.g. pindolol: indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A61K 31/343
Having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide: condensed with a carbocyclic ring, e.g. coumaran,…
A61K 31/4045
Indoles, e.g. pindolol: indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
A61P 35/00
Antineoplastic agents

Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-b]furan-2-carbohydrazide derivatives as an active ingredient

Life of this patent

Composition for prevention or treatment of cancer comprising N-methylenenaphtho[2,1-b]furan-2-carbohydrazide derivatives as an active ingredient

Life of this patent

Abstract

Claims8