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US 9,433,606 B2Granted
Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
AssigneeCelgene Corporation
InventorsGeorge W. Muller, Peter H. Schafer, Hon-Wah Man, Chuansheng Ge, Jean Xu
Life of this patent
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Abstract
Solid forms comprising (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions comprising the solid forms, methods of making the solid forms and methods of their use are disclosed. The methods include methods of treating and/or preventing disorders ameliorated by the reduction of levels of TNF-α or the inhibition of PDE4.
Claims15
A method of treating sarcoidosis, the method comprising administering to a patient having sarcoidosis a therapeutically effective amount of a Form B crystal form of the compound of Formula (I):
- which is enantiomerically pure, and which has an X-ray powder diffraction pattern comprising peaks at about 10.1, 13.5, 20.7, and 26.9 degrees 2θ.
Dependencies are inferred from the claim text.