US 9,433,593 B1Granted

Composition for anti-inflammation containing 5-adamantan-1-yl-N-(2,4-dihydroxy-benzyl)-2,4-dimethoxy-benzamide

AssigneeAmorepacific Corporation

InventorsYung Hyup Joo, Heung Soo Baek, Jeong Hwan Kim, Chang Geun Yi, Hyung Jun Lim, Hong-Ju Shin, Yongjin Kim, Jon Hwan Lee

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Abstract

5-Adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide disclosed in the present disclosure lacks toxicity and can exhibit superior anti-inflammatory effect. It exhibits superior anti-inflammatory effect, for example, by inhibiting the production of one or more of NO and PGE2, by inhibiting the activity of one or more of the transcription factors NF-κB and AP-1 or by inhibiting proinflammatory cytokines such as IL-1β.

Claims9

Dependent claims

A method for inhibiting one or more of the following activities in a subject suffering from inflammation:

(i) the production of one or more of NO and PGE2;
(ii) the expression of one or more of iNOS and COX-2;
(iii) the activity of one or more of the transcription factors NF-κB and AP-1;
(iv) the expression of the proinflammatory cytokine IL-1β,
wherein the method comprises administering an effective amount of 5-adamantan-1-yl-N-(2,4-dihydroxybenzyl)-2,4-dimethoxybenzamide of Chemical Formula 1, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof to a subject in need thereof:

2 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/085,628Filed 30 Mar 2016
Priority: KR 10-2015-004543531 Mar 2015
Granted: 6 Sep 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 31/166
Having aromatic rings, e.g. colchicine, atenolol, progabide: having the carbon of a carboxamide group directly attached to the aromatic ring, e.g.…
A23G 1/42
Characterised by the composition containing organic or inorganic compounds: containing microorganisms or enzymes; containing paramedical or…
A23G 3/36
Sweetmeats, confectionery or marzipan; Processes for the preparation thereof: characterised by the composition containing organic or inorganic…
A23G 4/12
Characterised by the composition containing organic or inorganic compounds: containing microorganisms or enzymes; containing paramedical or…

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