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US 9,433,576 B2Granted
Cationic dry powders
AssigneePulmatrix, Inc.
InventorsMichael M. Lipp, Jean C. Sung
Life of this patent
Estimating the term…
Abstract
The invention relates to respirable dry particles that contain one or more divalent metal cations, such as calcium, in an amount of less than 3% by weight, and to dry powders that contain the respirable particles. The dry particles can further contain an active agent, or can be used as carrier particles to deliver an active agent.
Claims19
A respirable dry powder comprising respirable dry particles that comprise
- a) magnesium lactate;
- wherein the magnesium lactate provides magnesium ion in an amount between about 0.1% and 2.9% by weight of the dry particle,
- b) a pharmaceutical agent, and
- c) a pharmaceutically acceptable excipient,
- wherein the respirable dry powder does not contain a phospholipid, and wherein the respirable dry particles have a volume median geometric diameter (VMGD) of 5 microns or less when measured at a dispersion pressure of 1 bar and a dispersibility ratio (1 bar/4 bar) of less than about 1.5 as measured by laser diffraction (RODOS/HELOS system), and wherein the respirable dry particles have a tap density of greater than 0.4 g/cc.
2 more elements
A respirable dry powder comprising respirable dry particles that comprise
- a) a calcium salt;
- wherein the calcium salt provides divalent metal cation in an amount between about 0.1% and 2.9% by weight of the dry particle, and
- b) a pharmaceutical agent,
- wherein the respirable dry powder does not contain phospholipid, and wherein the respirable dry particles have a volume median geometric diameter (VMGD) of 5 microns or less when measured at a dispersion pressure of 1 bar and a dispersibility ratio (1 bar/4 bar) of less than about 1.5 as measured by laser diffraction (RODOS/HELOS system), and wherein the respirable dry particles have a tap density of greater than 4 g/cc.
1 more element
Dependencies are inferred from the claim text.