Method of administering hyaluronan formulation for preventing and ameliorating osteoarthritis
AssigneeReyn Pharma, LLC
InventorJames D. Smith
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Abstract
Disclosed is a method for mitigating or ameliorating osteoarthritis in vertebrate subjects including administering to a subject a therapeutically effective amount of an exogenous hyaluronan formulation. Also disclosed is an oral or parenteral hyaluronan composition comprising a polydisperse hyaluronan and a pharmaceutically acceptable carrier, and a method of manufacturing the composition.
Claims41
A method for slowing, attenuating, mitigating, and/or ameliorating the loss of articular cartilage in a vertebrate subject, the method comprising orally administering a liquid composition comprising a therapeutically effective amount of exogenous polydisperse hyaluronan composition comprising a blend of hyaluronan polymers having different molecular masses from about 500,000 to about 2,500,000 Daltons and a pharmaceutically acceptable carrier to the subject, wherein the pH of the composition is between about 2.5 and about 4.5.
A method for stimulating endogenous production of hyaluronic acid by synoviocytes in a vertebrate subject comprising administering a composition comprising a therapeutically effective amount of exogenous polydisperse hyaluronan composition comprising a blend of hyaluronan polymers having different molecular masses from about 500,000 to about 2,500,000 Daltons, wherein the pH of the composition is between about 2.5 and about 4.5.
A method for slowing, attenuating, mitigating, and/or ameliorating joint discomfort in a vertebrate subject in need thereof, the method comprising orally administering to the subject a composition comprising a therapeutically effective amount of polydisperse hyaluronan having an average molecular weight of from about 500,000 to about 2,500,000 Daltons and a pharmaceutically acceptable carrier, wherein the pH of the composition is between about 2.5 and about 4.5.
A method for slowing, attenuating, mitigating, and/or ameliorating joint discomfort in a vertebrate subject in need thereof, the method comprising orally administering to the subject a dietary supplement comprising a therapeutically effective amount of polydisperse hyaluronan having an average molecular weight of from about 500,000 to about 2,500,000 Daltons and a pharmaceutically acceptable carrier, wherein the pH of the dietary supplement is between about 2.5 and about 4.5.
A method for reducing joint pain in a vertebrate subject in need thereof, the method comprising orally administering to the subject a dietary supplement comprising a therapeutically effective amount of polydisperse hyaluronan having an average molecular weight of from about 500,000 to about 2,500,000 Daltons and a pharmaceutically acceptable carrier, wherein the pH of the dietary supplement is between about 2.5 and about 4.5.
A method for supporting joint health in a vertebrate subject in need thereof, the method comprising orally administering to the subject a dietary supplement comprising a therapeutically effective amount of polydisperse hyaluronan having an average molecular weight from about 500,000 to about 2,500,000 Daltons and a pharmaceutically acceptable carrier, wherein the pH of the dietary supplement is between about 2.5 and about 4.5.
Dependencies are inferred from the claim text.