US 9,433,436 B2 · Therapeutic material delivery system for tissue voids and cannulated implants

Abstract

Described herein is a novel drug delivery assembly having particular applicability to the field of orthopedic and surgical medicine. The devices and assemblies described herein enable the efficient application and retention of potentially expensive therapeutic materials to very specific locations, particularly those associated with voids in bone and tissue. One particularly unique aspect of the present invention involves the introduction of constructs which promote the retention of therapeutic material in the target area of application for beneficial use, for example by forming a proximal barrier that prevents leakage of the therapeutic material out of the target area. Additionally, the present invention provides unique devices and methods for surgical introduction of such constructs. The present invention finds particular application in connection with introduction of stem and progenitor cells, bioactive molecules and bone scaffold materials in conjunction with bone voids and with the use of cannulated implants, such as bone screws (also surgical screws) and pins. The present invention also has beneficial use in the delivery of cancer drugs, antimicrobials, bone cements and other therapeutic materials.

Claims18

Dependent claims

An assembly for delivering therapeutic material into a void in a tissue or implanted prosthetic device, said void accessed by means of a proximal opening, said assembly comprising:

a. a flowable plug in a plug reservoir having a volume, a distal end and a proximal end and a linear axis extending therebetween;
b. one or more fluid cannulated flow tubes, each having a distal and a proximal ends;
wherein each of the proximal ends comprise an attachment point to a therapeutic fluid reservoir and each of the distal ends comprises a therapeutic fluid discharge point;
c. a flowable plug delivery structure comprising:
i. a plug reservoir cannula having a proximal end and a distal end and an axial bore extending therebetween, said bore comprising, in part, said flowable plug in said reservoir, and wherein said distal end comprises one or more flowable plug discharge ports serving as a path for discharging said flowable plug into said void;
ii. a plug pusher that transmits a force to said plug reservoir housing said flowable plug so as to discharge said flowable plug through said one or more flowable plug discharge ports into said void;
and
iii. a mechanism that coordinates discharge of said flowable plug through said one or more flowable plug discharge ports with a distalward axial displacement of said one or more fluid cannulated flow tubes into said void.

5 more elements

An assembly for delivering therapeutic material into a void in a tissue or implanted prosthetic device, said void accessed by means of a proximal opening, said assembly comprising:

a. one or more flowable plug delivery cannulas;
b. an assembly body having a proximal end and a distal end with a flowable plug discharge port at the distal end of said assembly body, wherein said discharge port is hydraulically connected to a flowable plug in a plug reservoir;
c. one or more fluid cannulated flow tubes, each having a proximal end and a distal end, wherein each of the proximal ends comprises an attachment point to a therapeutic fluid reservoir and each of the distal ends comprises a therapeutic fluid discharge point and wherein said distal ends of said one or more of said fluid cannulated flow tubes are at a point more distal to the assembly body than said flowable plug discharge port;
d. an adapter section at the distal end of said assembly body wherein said flowable plug discharge port and the distal ends of said one or more fluid cannulated flow tubes are located within a perimeter defining a surface wherein said surface is compatible with a medical implant or tissue void and provides at least a partial hydraulic seal with said void.

1 more element

Dependencies are inferred from the claim text.

Therapeutic material delivery system for tissue voids and cannulated implants

Life of this patent

Therapeutic material delivery system for tissue voids and cannulated implants

Life of this patent

Abstract

Claims18